Endocrine Abstracts

Introduction: Obesity has become an international epidemic, with complex multifactorial aetiology. Both modifiable and unchangeable risk factors must be identified, to target public health interventions. Some studies have suggested that earlier pubertal maturation increases risk of adult obesity, although others have found no relationship. We aimed to meta-analyse existing data and hypothesised that any association is likely to be confounded by childhood adiposity.<p class...

We describe the case of a 39-year-old lady who was diagnosed with acromegaly in 1997 with basal GH 89.9 mu/l with paradoxical rise to 152 mu/l on OGTT, her IGF-1 was 76 nmol/l refrange (9.5–45). She underwent transphenoidal hypophysectomy in 1998 for pituitary microadenoma and postoperatively her growth hormone level was 5 mu/l. Six months following surgery she had an OGTT during which she suppressed her growth hormone levels to a nadir of 5 mu/l and her IGF-1 was 46.1 nm...